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DESIGNING SYNTHETIC BIOTICS
Our Process
Synlogic combines expertise in molecular biology, microbial engineering and physiology with innovative tools and components, including our proprietary library of synthetic biology components, state-of-the-art metabolic gene circuitry and regulatory genetic switches, to design Synthetic Biotics.
STEP 1
ASSESS THE PROBLEM
We dive deep into the science to understand the underlying mechanism or metabolic dysfunction causing the disease and develop ideas to correct these problems.
- Target identification and validation
- Predictive modeling
- Bioinformatics
STEP 2
DESIGN SOLUTIONS
Using techniques adopted from molecular biology, we assemble and test biotic prototypes to carry out a function that will help treat the disease.
- Cutting-edge DNA assembly to target candidate pathways
- Mathematical models to predict pathway efficiency
- Proprietary switches and parts to permit control and tuning of engineered circuits
- Selection of an optimal microbial “chassis” or foundational microbe for our therapeutic
STEP 3
BUILD THE SYNTHETIC BIOTIC
Once we’ve fine-tuned the parts needed for Synthetic Biotics, we insert them into the genome of the microbe.
- Proprietary integration systems to direct stable insertion of genetic circuits into the chassis
- Unique functional assays
- In-house process development research and optimization
STEP 4
PATIENT EXPERIENCE
Our Synthetic Biotics are designed to be given orally to provide the easiest possible experience for patients. Currently, our drug candidates are provided as a dry powder, to be taken with a small amount of either water or apple juice.
- Biomarkers
- Expert microbiome network and bioinformatics tools to expand our understanding the disease and predict response