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Our Process

Synlogic combines expertise in molecular biology, microbial engineering and physiology with innovative tools and components, including our proprietary library of synthetic biology components, state-of-the-art metabolic gene circuitry and regulatory genetic switches, to design Synthetic Biotics.

STEP 1

ASSESS THE PROBLEM

We dive deep into the science to understand the underlying mechanism or metabolic dysfunction causing the disease and develop ideas to correct these problems.

  • Target identification and validation
  • Predictive modeling
  • Bioinformatics

STEP 2

DESIGN SOLUTIONS

Using techniques adopted from molecular biology, we assemble and test biotic prototypes to carry out a function that will help treat the disease.

  • Cutting-edge DNA assembly to target candidate pathways
  • Mathematical models to predict pathway efficiency
  • Proprietary switches and parts to permit control and tuning of engineered circuits
  • Selection of an optimal microbial “chassis” or foundational microbe for our therapeutic

STEP 3

BUILD THE SYNTHETIC BIOTIC

Once we’ve fine-tuned the parts needed for Synthetic Biotics, we insert them into the genome of the microbe.

  • Proprietary integration systems to direct stable insertion of genetic circuits into the chassis
  • Unique functional assays
  • In-house process development research and optimization

STEP 4

PATIENT EXPERIENCE

Our Synthetic Biotics are designed to be given orally to provide the easiest possible experience for patients. Currently, our drug candidates are provided as a dry powder, to be taken with a small amount of either water or apple juice.

  • Biomarkers
  • Expert microbiome network and bioinformatics tools to expand our understanding the disease and predict response

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