Our Process

Synlogic combines expertise in molecular biology, microbial engineering and physiology with innovative tools and components, including our proprietary library of synthetic biology components, state-of-the-art metabolic gene circuitry and regulatory genetic switches, to design Synthetic Biotics.



We dive deep into the science to understand the underlying mechanism or metabolic dysfunction causing the disease and develop ideas to correct these problems.

  • Target identification and validation
  • Predictive modeling
  • Bioinformatics



Using techniques adopted from molecular biology, we assemble and test biotic prototypes to carry out a function that will help treat the disease.

  • Cutting-edge DNA assembly to target candidate pathways
  • Mathematical models to predict pathway efficiency
  • Proprietary switches and parts to permit control and tuning of engineered circuits
  • Selection of an optimal microbial “chassis” or foundational microbe for our therapeutic



Once we’ve fine-tuned the parts needed for Synthetic Biotics, we insert them into the genome of the microbe.

  • Proprietary integration systems to direct stable insertion of genetic circuits into the chassis
  • Unique functional assays
  • In-house process development research and optimization



Our Synthetic Biotics are designed to be given orally to provide the easiest possible experience for patients. Currently, our drug candidates are provided as a dry powder, to be taken with a small amount of either water or apple juice.

  • Biomarkers
  • Expert microbiome network and bioinformatics tools to expand our understanding the disease and predict response

Brendan St. Amant

Brendan joined Synlogic in 2021 as Vice President, Head of Legal. Prior to joining Synlogic, he was Vice President, Legal, and member of the leadership team at Ohana Biosciences and was senior counsel at Vertex Pharmaceuticals. Brendan was previously an associate and partner at the law firm of Donnelly, Conroy & Gelhaar, LLP, in Boston where he focused on commercial controversies and government enforcement. Earlier in his legal career, Brendan served as a clerk for the U.S. District Court for the District of Connecticut and was an associate at the law firm of Goodwin Procter. He received his B.A. in History from Cornell University, J.D. from Harvard Law School, and his M.P.P from the Harvard Kennedy School. Brendan has served on several practice-related bar committees and on the executive committee of the Board of Trustees of the Massachusetts Continuing Legal Education corporation. 

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