Company Overview

At Synlogic: We are Putting LIFE Into Medicines
We are pioneers in the development of Synthetic BioticTM medicines, a novel class of LIVING medicines intended to transform the lives of patients with a broad range of diseases ranging from genetic and acquired metabolic diseases to inflammation and cancer.

Every day our teams work tirelessly to drive to deliver on 4 aspirations:

  • People: LIVING each day with passion for building up and building out our Synlogic team
  • Platform: Expanding and enhancing the technology to generate and protect novel LIVING medicines with new and versatile mechanisms of action
  • Products: Rapidly developing and commercializing Synthetic Biotics that transform the LIVES of patients and their families
  • Promise: Building our company to launch multiple novel LIVING medicines – mastering a new frontier in medicine

We combine Human Logic and Science Logic to drive meaningful work, careers, and LIFE at Synlogic. We foster a people-focused environment grounded in: Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire: Innovation, Integrity, High Performance, and LIFE Changing Results.

We continue to build and enhance our organization. If you want a settled environment, pursuing a well-walked path then this environment is probably not for you. If you want to join a growing company, work hard, and challenge yourself to find solutions at a new frontier of medicines then we would love to hear from you.

Job Description

Senior Metabolic Engineer:

Synlogic is a leading biotechnology/synthetic biology company located in Cambridge, MA that is focused on the development of novel therapeutic microorganisms for the treatment of important human diseases, including inborn errors of metabolism. We are currently seeking a motivated individual with experience in metabolic engineering in microbial systems to join our research team by contributing to the design, construction and evaluation of our engineered therapeutic organisms. The successful candidate will guide our existing team of strain engineers and serve as a resource to the discovery organization as a whole. This role represents a unique opportunity to guide the evolution of our innovative platform to new levels of therapeutic effectiveness by building on internal and external knowledge. The ideal candidate should be passionate about innovation, have cutting edge experience in microbial engineering technologies including metabolic modeling and flux analyses, and have proven experience leading diverse scientific teams.

Duties and Responsibilities

To contribute effectively in this role, the successful applicant will be expected to be proficient or have experience in:

  • metabolic engineering and bacterial strain development
  • microbial metabolism as related to industrial biotechnology
  • flux balance analysis
  • thermodynamic/kinetic analysis
  • systems biology and related analytical methodologies including transcriptomics
  • assay development
  • strain optimization methodologies including directed evolution and design of selections and screens

Qualifications & Experiences

Required Qualifications & Experiences: The following qualifications and experiences are required for the position:

  • PhD in chemical or biological engineering or an aligned discipline with 10+ years experience in an industrial biological engineering setting
  • Knowledge of diverse microbial engineering systems
  • Familiarity with diverse engineering contexts including anaerobiosis
  • Collaborative experience with scale-up and manufacturing organizations
  • Significant team leadership skills including teaching and knowledge sharing
  • Proven ability to coordinate team efforts towards aggressive goal delivery
  • Excellent written and oral communication skills
  • Ability to work effectively in a highly collaborative, cross-functional environment
  • Experience presenting working with and presenting to senior leaders, critical stakeholders and external audiences

Other Requirements

  • Occasional travel required.


We are at our best when we combine Human Logic and Science Logic to build great teams and deliver outstanding results. Our 6 values of Compassion, Fun, Trust & Respect, Innovation, Integrity and Results are central to our organization.

Our compassion for patients is the engine that drives our innovation and motivates our sense of urgency; always remembering that patients are waiting. Our compassion for each other creates a safe environment for continuous risk taking and personal development. We connect with our colleagues by having fun together. We take our work seriously and value integrity in producing the highest quality work. We trust each other, respecting all ideas and driving accountability to generate the best results for our patients and team. We encourage openness, direct feedback and transparency in decision-making to enable trust and maintain the nimbleness of the group.


To apply for this position please send your resume to:

Synlogic, Inc. is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.