Synlogic’s Synthetic Biotic™ medicines are designed to treat patients with metabolic diseases, including phenylketonuria (PKU) and Enteric Hyperoxaluria. We are rapidly advancing new Synthetic Biotic medicines to treat a range of diseases, including cancer, autoimmune and inflammatory conditions.
|Other Metabolic Program #1
|Other Metabolic Program #2
|Immuno-Oncology Solid Tumors
|Inflammatory Bowel Disease
Other Inflammatory Programs
|Exploratory||Preclinical||IND-Enabling Studies||Phase 1||Phase 2|
|Other Metabolic Program #1|
|Other Metabolic Program #2|
|Immuno-Oncology Solid Tumors||SYNB1891|
|Inflammatory Bowel Disease|
Other Inflammatory Programs
“We set out to identify diseases where we could have a meaningful impact and also demonstrate the power and potential of synthetic biology, leading us to focus on PKU and Enteric Hyperoxaluria as our initial indications. Once we understood the underlying molecular biology behind these conditions, we could rapidly design Synthetic Biotic™ medicines that could potentially provide new treatment options for patients.”
— Aoife Brennan, MB, ChB, President and Chief Executive Officer
Phenylketonuria (PKU) is an inherited metabolic disease that manifests at birth and is marked by an inability to break down Phe, an amino acid that is commonly found in many foods. Left untreated, high levels of Phe become toxic and can lead to serious neurological and neuropsychological problems affecting the way a person thinks, feels, and acts. Due to the seriousness of these symptoms, infants are screened at birth in many countries to ensure early diagnosis and treatment to avoid intellectual disability and other complications.
Enteric Hyperoxaluria is an acquired metabolic disorder caused by increased absorption of dietary oxalate, which is present in many healthy foods, making it almost impossible to control with diet alone. Enteric Hyperoxaluria often occurs as a result of a primary insult to the bowel, such as inflammatory bowel disease, short bowel syndrome, or as a result of surgical procedures such as Roux-en-Y bariatric weight-loss surgery. Enteric Hyperoxaluria results in dangerously high levels of urinary oxalate, which causes progressive kidney damage, kidney stone formation, and nephrocalcinosis. There are no approved treatment options.
Cancer cells are known for their ability to evade the body’s immune system, allowing them to persist, proliferate and metastasize. Synlogic is designing Synthetic Biotic medicines that work to combat the tumor’s ability to evade the immune system, boosting a patient’s immune response and promoting the body’s ability to detect and destroy cancer cells. Synlogic has advanced its first clinical candidate in cancer, SYNB1891, into a Phase 1 clinical trial in patients with advanced solid tumors and lymphoma. More information can be found at www.clinicaltrials.gov. SYNB1891 is designed to activate the STING pathway specifically in antigen presenting cells that naturally sense and engulf bacteria. This results in local ablation of cancer cells as well as targeting metastases that spread throughout the body.
Autoimmune & Inflammatory Disease
Synlogic is also developing novel Synthetic Biotic medicines to treat inflammatory bowel disease.
Synlogic is evaluating its Synthetic Biotic platform for the development of vaccines with differentiated clinical profiles.