Synlogic’s first Synthetic Biotic™ medicines are designed to treat patients with metabolic diseases, including phenylketonuria (PKU). We are rapidly advancing new Synthetic Biotic medicines to treat a range of diseases, including cancer and autoimmune and inflammatory conditions.

Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
Secondary hyperoxaluria
Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
Maple Syrup Urine Disease (MSUD)
Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
Immuno-Oncology Solid Tumors
Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
Additional Oncology Applications
Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
Inflammatory Bowel Disease
Preclinical Studies IND-Enabling Studies Phase 1 Phase 2
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Inborn Errors of Metabolism
Metabolic Disease

“We set out to identify diseases where we could have a meaningful impact and also demonstrate the power and potential of synthetic biology, leading us to focus on PKU and cancer as our initial indications. Once we understood the underlying molecular biology behind these conditions, we could rapidly design Synthetic Biotic™ medicines that could potentially provide new treatment options for patients.”

— Aoife Brennan, MB, ChB, Chief Executive Officer

Phenylketonuria (PKU)

Phenylketonuria (PKU) is a rare genetic disorder estimated to affect 16,500 people in the U.S., according to the National PKU Association. People with PKU are unable to process phenylalanine (Phe), an essential amino acid that enters the body as a component of dietary protein. PKU requires adherence to a strict diet to prevent the toxic accumulation of Phe in the blood and brain, which can impact neurological function. Synlogic has designed a Synthetic Biotic medicine, SYNB1618, to produce phenylalanine-degrading enzymes designed to lower Phe levels to allow those with PKU to consume more natural protein. We are currently conducting clinical trials of SYNB1618 in people with PKU to demonstrate safety and to test whether this could be a useful therapeutic option to help patients manage their blood Phe levels.

Immuno Oncology

Cancer cells are known for their ability to evade the body’s immune system, allowing them to persist, proliferate and metastasize. Synlogic is designing Synthetic Biotic medicines that work to combat the tumor’s ability to evade the immune system, boosting a patient’s immune response and promoting the body’s ability to detect and destroy cancer cells. Synlogic has advanced its first clinical candidate in cancer, SYNB1891, into a Phase 1 clinical trial in patients  with in patients with advanced solid tumors and lymphoma. More information can be found at SYNB1891 is designed to activate the STING pathway specifically in antigen presenting cells that naturally sense and engulf bacteria. This results in local ablation of cancer cells as well targeting metastases that spread throughout the body.

Autoimmune & Inflammatory Disease

Synlogic is partnering with pharmaceutical company AbbVie to develop novel Synthetic Biotic medicines to treat inflammatory bowel disease.