Company Overview

At Synlogic: We are Putting LIFE Into Medicines
We are pioneers in the development of Synthetic BioticTM medicines, a novel class of LIVING medicines intended to transform the lives of patients with a broad range of diseases ranging from genetic and acquired metabolic diseases to inflammation and cancer.

Every day our teams work tirelessly to drive to deliver on 4 aspirations:

  • People: LIVING each day with passion for building up and building out our Synlogic team
  • Platform: Expanding and enhancing the technology to generate and protect novel LIVING medicines with new and versatile mechanisms of action
  • Products: Rapidly developing and commercializing Synthetic Biotics that transform the LIVES of patients and their families
  • Promise: Building our company to launch multiple novel LIVING medicines – mastering a new frontier in medicine

We combine Human Logic and Science Logic to drive meaningful work, careers, and LIFE at Synlogic. We foster a people-focused environment grounded in: Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire: Innovation, Integrity, High Performance, and LIFE Changing Results.

We continue to build and enhance our organization. If you want a settled environment, pursuing a well-walked path then this environment is probably not for you. If you want to join a growing company, work hard, and challenge yourself to find solutions at a new frontier of medicines then we would love to hear from you.

Job Description

Scientist – Bioinformatics/Computational Biology

Synlogic is a leading biotechnology/synthetic biology company located in Cambridge, MA that is focused on the development of novel therapeutic microorganisms for the treatment of important human diseases, including inborn errors of metabolism. We are currently seeking a motivated scientist with experience in genomics and bioinformatics for position with our translational research team to contribute to our Next Generation Sequencing (NGS) software pipeline development and strain characterization efforts. The successful candidate will develop and validate software pipelines to automate metagenomic and transcriptomic data analysis and visualization to enable characterization of microbial communities and engineered strain functional profiles. In addition, this role will develop predictive modeling strategies to combine NGS and metabolomics datasets to anticipate strain activity in simulated gastrointestinal tract (GI) and animal models. The ideal candidate should have experience in NGS data processing, multivariate analysis techniques, mathematical modeling, and data visualization, as well as software development and validation. This role represents a unique opportunity to meaningfully advance our understanding of engineered bacterial strain physiology and activity in the host environment.

 

Duties and Responsibilities

  • Develop and rigorously validate NGS and metabolomics data processing and visualization software pipelines.
  • Characterize metagenomic signatures of treatment with therapeutic microorganisms.
  • Identify differentially expressed bacterial genes/pathways in simulated GI models.
  • Construct and validate predictive models of therapeutic strain activity.
  • Prepare Next Generation Sequencing (NGS) libraries, and operate/maintain NGS instruments.
  • Implement data storage, documentation, and quality protocols in collaboration with Synlogic’s IT staff.
  • Generate data reports, rigorously maintain an electronic laboratory notebook, and accurately present data to project teams.

 

Qualifications & Experiences

  • MS with 5+ years experience or PhD in Genomics, Bioinformatics, Computer Science, or a relevant field.
  • Demonstrated experience with bioinformatics software development and NGS data analysis.
  • Deep understanding of statistical methods for interpreting ‘omics datasets.
  • Fluency with Linux, Bash, Python, and related statistical and data visualization software packages.
  • Experience with cloud computing solutions.
  • Experience with transcriptomic, metagenomic, or metabolomic datasets.
  • Experience with multivariate analysis techniques.
  • Experience with machine learning methods preferred.
  • Experience with constructing relational databases preferred.
  • Molecular Biology skills for NGS library construction a plus.
  • Strong attention to detail and accuracy and an ability to work independently to solve technical problems.
  • Highly organized with excellent written and oral communication skills
  • Effective management of time and effort to meet deadlines.
  • Ability to work effectively in a highly collaborative, cross-functional environment.

Other Requirements

Behaviors

We are at our best when we combine Human Logic and Science Logic to build great teams and deliver outstanding results. Our 6 values of Compassion, Fun, Trust & Respect, Innovation, Integrity and Results are central to our organization.

Our compassion for patients is the engine that drives our innovation and motivates our sense of urgency; always remembering that patients are waiting. Our compassion for each other creates a safe environment for continuous risk taking and personal development. We connect with our colleagues by having fun together. We take our work seriously and value integrity in producing the highest quality work. We trust each other, respecting all ideas and driving accountability to generate the best results for our patients and team. We encourage openness, direct feedback and transparency in decision-making to enable trust and maintain the nimbleness of the group.

TO APPLY

To apply for this position please send your resume to: joinus@synlogictx.com

Synlogic, Inc. is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.