Precision Programming of the Microbiome

Precise programming of naturally-occurring microbes using synthetic biology enables therapeutic impact throughout the body.

Based on its size, organization and specialized functions, the microbiome is now widely considered a distinct organ – one that carries out activities essential to our well-being.
Synlogic’s therapeutic approach is to augment the innate activities of the microbiome with programmed metabolic capabilities to drive therapeutic effects. Using our synthetic bioticsTM approach, we provide a stable, non-colonizing fraction of the microbiome to patients to correct metabolic dysregulation in certain diseases and synthesize substances that treat disease in others.

Synlogic achieves the therapeutic programming of synthetic biotics by engineering a probiotic bacteria to carry specialized assemblies of DNA called genetic circuits. These genetic circuits allow the synthetic biotic to sense a patient’s internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the synthetic biotic completes all of the necessary, programmed steps in order to achieve therapeutic effect.