Careers

 

Synlogic Therapeutics is an innovative biopharma company in Cambridge, MA. We are driving development of medicines from a unique position at the convergence of two revolutionary fields: synthetic biology and the microbiome. We offer a dynamic work environment where our dedicated team pursues R&D activities spanning drug discovery through clinical development. We are committed to the service of patients, to the pursuit of innovation and to maintaining a vibrant and welcoming culture.

Full-time Opportunities:

BioProcess Engineer II/III

Position Description:

We are currently seeking a highly motivated and enthusiastic BioProcess Engineer II/III to contribute to development of fermentation and downstream processes for manufacturing of our engineered probiotics. The successful candidate will be part of a dynamic and motivated development team, helping to bring Synlogic’s novel synthetic biotics to clinical trials and eventual commercialization.  As part of this effort, the successful candidate will provide knowledge and skills in the following areas:

  • Lab operations to support microbial fermentation and downstream process development, optimization, and validation
  • Provide day-to-day support for bench scale bioreactor operation, including: media prep, inoculation, bioreactor prep, process monitoring, sampling, and harvesting
  • Design, support, and perform fermentations in a microfermentation system (AMBR 15F)
  • Support operation of downstream activities as needed, such as centrifugation, TFF, and lyophilization
  • Perform process monitoring using a variety of data analysis methods and techniques (e.g., excel, JMP, etc.)
  • Perform quality assays such as cell plating, flow cytometry, plate-based biochemical assays, etc.
  • Generate internal documentation such as protocols, study proposals, and reports
  • Present data at weekly group meetings
  • Provide technical support for technology transfer operations
  • Train and mentor Co-op students
  • Help maintain a clean, safe, and functional lab environment

Education and Experience Requirements:

  • B.S./M.S. in bio/chemical engineering, or related
  • 2-5 (II) or 5-9 (III) years hands-on laboratory experience in microbial fermentation at the flask to fermenter scale, preferably industry experience
  • Knowledge of biotechnology unit operations, process control, biochemical engineering, and process data analysis
  • Highly motivated individual with the ability to work independently as well as on cross-functional teams

About Synlogic:

Synlogic is a privately-held biopharmaceutical company based in Cambridge, Massachusetts, pioneering the development of a novel class of therapeutics, called synthetic biotics, based on its proprietary synthetic biology and microbiome platform. The synthetic biotics are programmed to correct disease-causing metabolic dysregulation while operating within the microbiome. We are utilizing state-of-the-art synthetic biology and microbial genetics technologies to build a promising portfolio of investigational clinical candidates.  For more information, please visit http://synlogictx.com/.

To apply for this position please contact Pip Reeder at pip@synlogictx.com

Synlogic Therapeutics is committed to equal employment opportunity.  All applicants must have authorization to work in the U.S.

 

Director/Senior Director Program Management

Job Description

Synlogic is a leading biotechnology company located in Cambridge, MA, that engineers synthetic biotics, a new class of medicines, designed from natural probiotic bacteria that are programmed to correct disease-causing metabolic dysregulation while operating within the microbiome. We are utilizing state-of-the-art synthetic biology and microbial genetics technologies to build a promising portfolio of investigational clinical candidates.

Position description:
Synlogic is seeking a Director/Sr Director of Program Management to join their team. Reporting to SVP of Translational Sciences, this individual will help build a Program Management function focused on creating scientifically driven program managers and leaders.  Supporting early stage teams in a new platform of programs, this function must assure that teams are aligned on goals, have excellent cross-functional communication and integration of activities, and manage to timelines and budget while driving from a strong scientific foundation.  Alliance management skills and experience working with external partnerships is an important skill for this role.  The successful candidate will both lead a cross functional team as well as build functional capabilities in the organization for timeline and budget management.

This is a unique and exciting opportunity to help develop synthetic biotics as therapies for immune system, immune oncology and metabolic diseases.

Primary Responsibilities include:

  • Establish and direct R&D program management processes including prioritization of key project objectives, go/ no go decisions, data review based on key milestones and assist in the compilation and tracking of program budgets to maximize value of the assets in alignment with the company’s goals and objectives. This position will also have a key role in identification of key resource gaps and program risks, implementation of mitigations plans and development of product development contingency plans.
  • Develop and implement timelines (Gantt charts), project status reports, agenda, meeting minutes and timelines for tracking of interdependencies of project deliverables.
  • Support the executive staff with the development and tracking of project goals and deliverables within the context of the corporate goals.
  • Development of governance processes to enable efficient and effective decision making.
  • Development of project plans and deliver results while adhering to pre-determined budgets and timelines. Works with finance to assist in the development of project budgets and tracking project costs.
  • Understands the cross functional interdependencies to advance programs from discovery through clinical development.
  • Provide periodic status reports to executives and coordinate documentation and archiving of project deliverables and key decisions.
  • Build and drive project teams through clear designation of team and individual roles and responsibilities.
  • Communicate effectively across all functional areas so that all deliverables and interdependencies are clear.
  • Proactively identifies project challenges such as resource, technical and scheduling constraints and assists in their resolution via risk assessments tools.

Requirements for this role:

  • PhD or MS in Biology, Biochemistry, Microbiology, Immunology or related field with 10+ years of pharmaceutical industry experience
  • 5+ years experience leading/managing cross-functional development teams through clinical development and regulatory filings
  • Exceptional leadership, interpersonal communications, across all levels within the organization
  • Excellent judgement in making trade-off decisions for program scope, costs and strategy
  • Mastery in use of Program Management tools to assure clear communication and coordination of cross-functionaol team activities and accountability, and achievement of agreed upon company goals and timelines
  • Expereince with managing regulatory submissions
  • Fosters collaboration and positive team environment
  • Experience with biologics or rare disease drug development programs desirable

To apply for this position please contact Caroline Kurtz at caroline@synlogictx.com

Synlogic Therapeutics is committed to equal employment opportunity.  All applicants must have authorization to work in the U.S.

 

Director of Bioanalytical

Job description

At Synlogic, our vision is to create an entirely new modality of therapeutic agents – engineered probiotic bacteria that operate as living medicines to treat important diseases.  We are making this dream a reality with the advancement of several projects towards clinical development, and are looking to strengthen our talented team with the addition of an experienced scientific leader to help evolve our bioanalytical strategy.

We are seeking an experienced individual who is excited by the prospect of establishing DMPK models for a new class of therapeutic agents.  This individual will have experience working across the drug discovery and development continuum, including a track record of successfully managing R&D portfolio workflows through a combination of internal resources and CROs, as well as an ability to support regulatory interactions and related document preparatory processes.  The successful candidate will have expertise in small molecule bioanalytical method development strategies and instrumentation (LC-MS/MS and GC-MS) as well as establishment of appropriate assays to support discovery and early clinical development.  Importantly, this individual should have metabolomics experience including untargeted metabolite identification and characterization. Strong supervisory and communication skills and the ability to facilitate constructive, expedient problem solving are also essential, as are excellent writing and editing skills with an attention to detail.  A PhD with 7-10 years of industrial experience are required.

To apply for this position please contact Paul Miller at paul@synlogictx.com

 

 

Director Formulation Development, Drug Substance and Drug Product

Position Description

The Director of Formulation Development will lead the development of formulations for drug substance and drug product at Synlogic. The Director will be responsible for transfer of the DS and DP formulation process to contract GMP manufacturers and for monitoring those production processes with the process development staff. The Director will be part of a dynamic and motivated Development team to bring Synlogic’s novel synthetic biotics to clinical trials and eventual commercialization. As part of this effort, the person will be expected to:

  • Develop and execute plans for development of dried drug substance formulations and solid oral dosage forms of drug product. This work would be a performed through a combination of contract and internal development.
  • Develop and execute plans for supply of solid oral dosage forms of R&D products for non-clinical studies.
  • Lead the evaluation and selection of contractors for the development and GMP manufacturing of Synlogic DS and DP.
  • Lead the tech transfer and production of Synlogic formulated product forms internally and at CDMOs.
  • Prepare timelines and budgets for formulation development and production related activities.
  • Lead formulation development project teams and represent the formulation work in cross-functional team meetings.
  • Write and review development technical protocols and technical reports documenting formulation, stability and method development studies as required for internal documentation.
  • Write and review work documenting formulation, stability and method development studies as required for IND and other regulatory submissions.

Education and Work Requirements

  • D. in Pharmaceutics, Biology, Chemistry or a related discipline.
  • Minimum of 15 years’ experience post-Ph.D. with at least 10 years of industry experience in formulation development of DS and DP.
  • Experience independently leading multiple formulation development projects.
  • Confident oral and written communication skills.

Required Technical Skills

The applicant must have demonstrated experience with the majority of the following analytical methods:

  • Protein Spectroscopic Analysis (DSF, FTIR, CD)
  • Calorimetric analysis (DSC)
  • Particle sizing and characterization (DLS, HIAC, and/or MFI)
  • Physico-chemical solution analysis (Osmometry and/or Viscometry)
  • Familiarity with computer software including word processing and data evaluation (SigmaPlot, GraphPad, Origin, and/or JMP DOE software).

The applicant must have demonstrated experience in the following scientific areas:

  • Experience with formulation development studies, including excipient screening and optimization for formulation of dry biological products as drug substances. This should include lyophilization or spray drying.
  • Experience with solid dosage form development for DP, including capsuling, tableting and enteric coating.
  • Experience transferring formulation processes to GMP manufacturing operations
  • Experience generating and executing stability studies.

About Synlogic

Synlogic is a privately-held biopharmaceutical company based in Cambridge, Massachusetts, pioneering the development of a novel class of therapeutics, called synthetic biotics, based on its proprietary synthetic biology and microbiome platform. The synthetic biotics are programmed to correct disease-causing metabolic dysregulation while operating within the microbiome. We are utilizing state-of-the-art synthetic biology and microbial genetics technologies to build a promising portfolio of investigational clinical candidates. For more information, please visit http://synlogictx.com/.

IF INTERESTED, PLEASE CONTACT

Richard M. Schwartz, Senior Vice President, Development and Manufacturing, Synlogic

Phone: 607-202-9373, dick@synlogictx.com

 

Sr. Scientist, Nutritional/Metabolic Pharmacology

Job Description

Synlogic is a leading biotechnology company located in Cambridge, MA, that engineers synthetic biotics, a new class of medicines, designed from natural probiotic bacteria that are programmed to correct disease-causing metabolic dysregulation while operating within the microbiome. We are utilizing state-of-the-art synthetic biology and microbial genetics technologies to build a promising portfolio of investigational clinical candidates.

Position description:

Synlogic is seeking a highly motivated pharmacologist/nutritional scientist with expertise in metabolism and gastrointestinal physiology. This individual will help build a team focused on in vivo model systems to study the therapeutic potential of engineered probiotics. An important emphasis of this position will be to establish and leverage mammalian in vivo model systems to address key questions about the efficacy of our engineered probiotics operating within the gastrointestinal system and the microbiome as an integral point for modulation of systemic metabolic disease. The successful candidate will work with our internal team, external experts and CROs to leverage their experience in metabolic or nutritional pharmacology and implement novel experimental systems to trace and characterize key metabolites and nutrients including amino acids and short chain fatty acids in the body. This is a unique and exciting opportunity to help develop synthetic biotics as therapies for inborn errors of metabolism, such as UCD and PKU and other chronic metabolic diseases and establish a new therapeutic modality that is leveraging the GI tract, and the power of synthetic biology towards the treatment of rare and intractable human diseases.

Requirements for this role:

  • PhD and 10+ years of relevant research experience in industry
  • Significant experience in research and development for metabolic disease indications
  • Understanding of amino acid or short chain fatty acid metabolism desirable
  • Experience developing in vivo models and their application to therapeutic discovery and development
  • Strong analytical and problem solving capabilities
  • Track record of successful external collaboration with key opinion leaders
  • Experience working in cross functional multidisciplinary teams and leading a pharmacology group

To apply for this position please contact Caroline Kurtz at caroline@synlogictx.com

Synlogic Therapeutics is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.